Fig. 5.

Experimental kidney disease (CKD) induced significant glomerulosclerosis and tubule/interstitial fibrosis in both kidneys. A: representative protein expression (3 bands/group) of profibrotic transforming growth factor-β (TGFβ), connective tissue growth factor (CTGF), and tissue remodeling factors matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitors of metalloproteinases (TIMP-1). Representative renal cross-sections stained with trichrome (×20), shown as examples to illustrate (B) and quantify (C) the degree of renal fibrosis after 14 wk of CKD. *P < 0.05 vs. normal.