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Targeted regions of the polycystic kidney disease 2 (PKD2) gene in individual clonal human embryonic kidney (HEK-293) cell lines. Individual panels show sequences of targeted PKD2 regions from wild-type (WT) and mutant cell lines; labels show mutation description in the PKHD1 cDNA and resulting protein defects. In the case of p.Ser804Valfs and p.Phe805Leufs, frameshifts extend beyond the end of targeted exons.
