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. 2019 Apr;29(4):646–656. doi: 10.1101/gr.240739.118

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© 2019 Sharim et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — Comparison of long-range methylation profiles of single molecules. (A) Global view of Chromosome 1: 6,350,000–6,670,000 (bp). (B) Locations of CpG islands across the specified region. (C) Density of M.TaqI sites across the specified region in a 1.5-kb sliding window. (D) ROM fluorescence intensity profiles of three detected molecules aligned to the specified regions based on genetic labels (P-value <10⁻²⁰). (E) Gene body locations and corresponding HGNC gene symbols. Each gene is displayed as a purple arrow indicating gene orientation. (B–E) Black and red rectangles indicate methylated and nonmethylated gene promoters overlapping with CGIs, respectively.