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. 2019 Apr;29(4):576–589. doi: 10.1101/gr.239863.118

Figure 4.

Figure 4.

Association of transcription factor binding sites (TFBSs) with the different types of EBRs and their branches of origin. (A) Frequency of motifs in enhancers near each type of EBR according to their branch of origin. The frequency has been normalized by branch length of each classification. The dotted line corresponds to the total frequency of each branch of origin. (B) TFs with a different frequency of motifs in each lineage-specific EBR type. It shows the frequency of each motif in enhancers found in or ±50 kbp of EBRs. The TF motifs are colored according to their TF family: Blue TFs are part of the More than 3 adjacent zinc fingers; green TFs belong to the Three-zinc finger Krüppel-related factors; mauve TFs are in the AP-2 family; whereas gray are part of other TF families. The pink, purple, and orange lines in both A and B correspond to bovid-to-cattle lineage, ruminant- and cetartiodactyl-specific EBRs, respectively. Color-coded asterisks, according to the type of EBR, show significantly different frequencies (goodness-of-fit P-value <0.05). Additional data can be found in Supplemental Tables S13 and S14.