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. 2019 Apr;29(4):576–589. doi: 10.1101/gr.239863.118

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© 2019 Farré et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — A model for the evolution of chromosome rearrangements with gene expression divergence by means of lineage-specific transposable elements (TEs). Chromosome rearrangement boundaries (EBRs) are enriched for lineage-specific TEs. These TEs harbor a higher number of TFBSs than ancestral TEs; therefore, they have a higher affinity for TFs and a stronger influence in gene expression and regulation than those found elsewhere in the genome. This leads to a higher differential expression for orthologous genes between species with and without the gross genomic rearrangement. Brown and green boxes represent ancestral or lineage-specific TEs, respectively. Purple bars represent TFBSs, and black boxes represent genes. Orange bell-shaped curves represent peaks of H3K27ac as functional enhancers, with the height of the bell proportional to the strength of the enhancer.