FIG. 1.

Heatmap summary of botanical/dietary substance activity in Tox21 assay panel. Each row is representative of a single test substance and each column is representative of a single in vitro assay. Assays are categorized by the relevant biological effect and the direction of effect being measured. The observed POD, a measure of relative potency in each assay, is indicated by the color scheme yellow (more potent) to purple (less potent). No coloration is indicative of no conclusive POD. Test substances (left; y-axis dendrogram) are grouped into clusters of similar activity profiles and assays are clustered (top; x-axis dendrogram) according to concordance of activities across test substances. POD, point of departure.