Fig. 1.

p27^Kip1 regulates cytoskeleton dynamics. The main findings regarding the interaction of p27 with proteins that impact on cytoskeleton dynamics are depicted. On the left, p27^Kip1 impacts on the microtubule cytoskeleton. p27 inhibits migration and invasion of neoplastic cells via stathmin [10], guarantees a proper extension of neurites [8], axonal transport velocity in neurons [12] and regulates cytokinesis limiting PRC1 activity [13]. On the right, p27^Kip1 impacts on the actin cytoskeleton. The fusion protein TAT-p27 stimulates migration in hepatocellular carcinoma cells and correlates with Rac1 activity [5, 6]; p27 inhibits RhoA activity, determining actomyosin stabilization [7] and neuronal nucleokinesis [8]. p27-NLS variant, which accumulates into the cytoplasm, results in increased motility in MCF7 breast cancer cells [15]; p27 binds citron-kinase impinging on the downstream activation of RhoA, thereby regulating cytokinesis [9]