Table 3.
List of the identification of potential biomarkers among groups.
| No. | Biomarker identification | m/z | ppm | ESI mode | Rt/min | Formula | B vs. A | D1 vs.B | D2 vs. D1 | Pathway |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | UMP | 324.21578 | 7.38 | + | 0.78 | C9H13N2O9P | ↓# | ↓ | ↑ | Pyrimidine metabolism |
| 2 | L-Lysine | 147.11222 | 0.07 | + | 0.98 | C6H14N2O2 | ↑ | ↑∗ | ↓△ | Lysine biosynthesis |
| 3 | Carnitine | 162.11193 | 6.44 | + | 1.13 | C7H15NO3 | ↓ | ↓∗∗ | ↑△ | Bile secretion |
| 4 | L-Arginine | 175.11846 | 1.68 | + | 1.14 | C6H14N4O2 | ↑ | ↑∗ | ↓△ | Arginine and proline metabolism |
| 5 | N-Formylanthranilic acid | 166.04688 | 18.18 | + | 2.83 | C8H7NO3 | ↓ | ↓∗ | ↓ | Tryptophan metabolism |
| 6 | Adenosine | 265.94792 | 7.65 | − | 9.60 | C10H13N5O4 | ↓ | ↓∗ | ↑ | Purine metabolism |
| 7 | Deoxycholic acid | 391.28221 | 0.28 | − | 12.10 | C24H40O4 | ↑ | ↑∗∗ | ↑ | Bile secretion |
↑: the compound was upregulated; ↓: the compound was downregulated.
# P < 0.05, compared with control group; ##P < 0.01, compared with control group; ###P < 0.001, compared with control group.
∗ P < 0.05, compared with model group; ∗∗P < 0.01, compared with model group; ∗∗∗P < 0.001, compared with model group.
△ P < 0.05, compared with D1 group; △△P < 0.01, compared with D1 group; △△△P < 0.001, compared with D1 group.