Table 4.
Regression analysis (Studied SNP's association with response Status (n=712, adjusted by Sex+Age+BMI).
| SNPs | Model | Genotype | RA | OA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Status=Cases | Status=Control | P-value | AIC | BIC | Status= Cases |
Status= Control |
P-value | AIC | BIC | |||
| rs10735810 | Dominant | T/T | 27 (9%) | 397 (96.4%) | <0.0001 | 321.7 | 344.5 | 1 (0.3%) | 397 (96.4%) | <0.0001 | 132.1 | 159.5 |
| C/T-C/C | 273 (91%) | 15 (3.6%) | 309 (99.7%) | 15 (3.6%) | ||||||||
| Recessive | T/T-C/T | 139 (46.3%) | 412 (100%) | <0.0001 | 611.4 | 634.3 | 204 (65.8%) | 412 (100%) | <0.0001 | 702.8 | 730.3 | |
| C/C | 161 (53.7%) | 0 (0%) | 106 (34.2%) | 0 (0%) | ||||||||
|
| ||||||||||||
| rs7975232 | Dominant | T/T | 12 (4%) | 411 (99.8%) | <0.0001 | 123.3 | 146.1 | 6 (1.9%) | 411 (99.8%) | <0.0001 | 52.7 | 80.2 |
| G/T-G/G | 288 (96%) | 1 (0.2%) | 304 (98.1%) | 1 (0.2%) | ||||||||
| Recessive | T/T-G/T | 141 (47%) | 412 (100%) | <0.0001 | 637 | 659.8 | 227 (73.2%) | 412 (100%) | <0.0001 | 735.8 | 763.3 | |
| G/G | 159 (53%) | 0 (0%) | 83 (26.8%) | 0 (0%) | ||||||||
|
| ||||||||||||
| rs1544410 | Dominant | G/G | 27 (9%) | 412 (100%) | <0.0001 | 208.8 | 231.7 | 194 (62.6%) | 412 (100%) | <0.0001 | 562.5 | 590 |
| A/G-A/A | 273 (91%) | 0 (0%) | 116 (37.4%) | 0 (0%) | ||||||||
| Recessive | G/G-A/G | 91 (30.3%) | 412 (100%) | <0.0001 | 484.6 | 507.5 | 79 (90%) | 412 (100%) | <0.0001 | 771 | 798.5 | |
| A/A | 209 (69.7%) | 0 (0%) | 31 (10%) | 0 (0%) | ||||||||
|
| ||||||||||||
| rs731236 | Dominant | T/T | 126 (42%) | 412 (100%) | <0.0001 | 510.6 | 533.4 | - | - | - | - | - |
| A/T-A/A | 174 (58%) | 0 (0%) | - | - | ||||||||
| Recessive | T/T-A/T | 285 (95%) | 412 (100%) | <0.0001 | 947 | 969.8 | - | - | - | - | - - |
|
| A/A | 15 (5%) | 0 (0%) | - | - | ||||||||
AIC=Akaike information criterion; BIC=Bayesian information criterion; P-value<0.01=significant.