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. 2019 Mar 7;116(13):6435–6440. doi: 10.1073/pnas.1816626116

Fig. 4.

Fig. 4.

RIPGBM reduces GBM tumor growth in an orthotopic intracranial xenograft model. (A) GBM39 patient-derived neurosphere cells engineered to stably express the IR protein 720 (IRFP 720) were orthotopically injected into 5-wk-old nu/nu mice. Mice were treated with vehicle or RIPGBM 50 mg/kg orally twice daily (n = 8 for vehicle and n = 6 for RIPGBM). (B) Representative FMT images of mice at week 5. (C) Representative H&E stains of mouse brains from mice at week 5. Values shown are mean ± SD (*P < 0.05 and **P < 0.01).