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. 2019 Mar 13;116(13):6162–6171. doi: 10.1073/pnas.1814139116

Fig. 3.

Fig. 3.

Depleting mouse liver miR-122 greatly attenuates lung inflammation and tissue damage induced by injured liver. (A) Relative level of miR-122 in mouse liver following miR-122 TuD AAV8 administration. (B) Relative levels of miR-122 in mouse plasma (Left) and lungs (Right) in control mice (Control), miR-122 TuD mice (miR-122 TuD), control mice treated with ConA (Control+ConA), and miR-122 TuD mice treated with ConA (miR-122 TuD+ConA). (C) Mouse lung tissue damage analyzed by H&E staining (Left) and injury score (Right). (D) Representative images (Left) and analysis (Right) of F4/80+ macrophage infiltration into mouse lungs. (E) FACS analysis of F4/80+CD11b+ macrophages in BAL harvested from the recipient mice (six mice per group, n = 3). (F) Levels of TNF-α (Left) and IL-6 (Right) in BALF from the four group mice (six mice per group, n = 3). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Student’s two-tailed, unpaired t-test (A), or one-way ANOVA followed by Bonferroni’s multiple comparisons test (B–F).