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. 2019 Mar 8;116(13):6146–6151. doi: 10.1073/pnas.1817259116

Fig. 4.

Fig. 4.

P. aeruginosa-secreted phenazines allow worms to detect the pathogen and initiate a protective antibacterial response. (A) zip-3(gk3164);hsp-6pr::gfp worms on wild-type P. aeruginosa or P. aeruginosa-∆phz. (Scale bar, 0.1 mm.) (B) Representative images of TMRE-stained wild-type worms on E. coli treated with DMSO or phenazines. (Scale bar, 0.1 mm.) (C) hsp-6pr::gfp or zip-3Y167A;hsp-6pr::gfp worms raised on E. coli treated with DMSO or phenazines. (Scale bar, 0.1 mm.) (D) Survival of wild-type and zip-3(gk3164) worms exposed to P. aeruginosa or P. aeruginosa-∆phz. Statistics are given in SI Appendix, Table S5. (E) Survival of wild-type and atfs-1(cmh15) worms exposed to P. aeruginosa or P. aeruginosa-∆phz. Statistics are given in SI Appendix, Table S5. (F) Schematics of the interactions between P. aeruginosa, mitochondrial perturbation, and UPRmt repression via ZIP-3.