Table 1.
Phenotypes | SNPs |
||||||
---|---|---|---|---|---|---|---|
rs749451 (C/T) |
rs888663 (T/G) |
rs1054564 (C/G) |
|||||
Beta | SE | Beta | SE | Beta | SE | ||
Anthropometry | GDF15 | 0.2129 | 0.0186 | 0.3012 | 0.0243 | 0.3083 | 0.0255 |
BMI | 0.0036 | 0.0018 | −0.0031 | 0.0022 | 0.0006 | 0.0025 | |
WHR | 0.0035 | 0.0046 | 0.0037 | 0.0059 | 0.0071 | 0.0063 | |
WC | 0.0024 | 0.0047 | −0.0006 | 0.006 | 0.003 | 0.0063 | |
WBLM | −0.0511 | 0.0382 | −0.0935 | 0.0476 | −0.0237 | 0.0443 | |
Fat percentage | −0.0037 | 0.0061 | −0.0036 | 0.0077 | −0.0038 | 0.0079 | |
Glycaemic trait | T2Da (BMI adjusted) | 0.0045 | 0.015 | −0.0023 | 0.019 | 0.022 | 0.021 |
T2Da | 0.0044 | 0.013 | −0.016 | 0.016 | 0.015 | 0.018 | |
FG (BMI adjusted) | −0.0017 | 0.0036 | 0.0037 | 0.0047 | −0.0005 | 0.0049 | |
FG | 0.0004 | 0.0035 | 0.0055 | 0.0046 | 0.0005 | 0.0047 | |
A1c | −0.0012 | 0.0019 | 0.0001 | 0.0024 | 0.0075 | 0.0026 | |
FI (BMI adjusted) | 0.0055 | 0.0029 | 0.0028 | 0.0038 | 0.0022 | 0.0042 | |
FI | 0.0084 | 0.0035 | 0.0051 | 0.0046 | 0.0032 | 0.0049 | |
Lipids |
LDL-C | −0.0062 | 0.0061 | −0.0091 | 0.0078 | 0.0022 | 0.0079 |
HDL-C | −0.006 | 0.0057 | −0.0076 | 0.0075 | −0.0258 | 0.0072 | |
TC | −0.0059 | 0.0059 | −0.0108 | 0.0076 | −0.0021 | 0.0077 | |
TG |
0.011 |
0.0054 |
0.0012 |
0.0069 |
0.007 |
0.0071 |
|
CADa | −0.0109 | 0.0086 | −0.0296 | 0.0108 | 0.0077 | 0.0121 | |
eBMD | 0.0058 | 0.0019 | 0.013 | 0.0024 | 0.0013 | 0.0026 |
Body mass index (BMI), waist-hip ratio (WHR), waist circumference (WC), whole-body lean mass (WBLM), Type 2 Diabetes (T2D), fasting glucose (FG), glycated haemoglobin (A1c), fasting insulin (FI), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), coronary artery disease (CAD), and estimated bone mineral density (eBMD).
Beta estimates are reported as ln(OR)s.