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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Med Chem. 2018 Sep 25;61(19):8811–8824. doi: 10.1021/acs.jmedchem.8b00964

Figure 3.

Figure 3.

(A-F) Axial T1-weighted images recorded at 4.7T capturing the liver and psoas muscle collected prior to (A-C) and 7 min after (D-F) injection of 4 (A,D), 6 (B,E), and 10 (C,F). (G) Liver vs. muscle ΔCNR recorded 7 min post-injection indicates that liver enhancement is greatest for the most lipophilic complex 10. (ΔCNR for 10 vs. 4, P = 0.0164, N=4 for 4 and 6, N=7 for 10). (H) Injected Mn recovered from the liver 10 min after injection is greatest for 10 (N=4 each). Note that significant washout of 10 has already occurred by 10 min (see Fig 3F) (I) Liver:blood Mn ratio 10 min after injection is significantly is higher for 10 than for 4 or 6 (P < 0.0001 for both). The rapid blood clearance and strong transient liver uptake of 10 are ideal properties for an agent designed to detect liver malignancies. Data reported as mean±SD. *P < 0.05, **** P < 0.0001.