Table 1.

Cellular localization of microRNAs described in biomarker studies in the review

microRNAa	Cell-type enrichment
Let-7e	Ubiquitous
miR-19b	Ubiquitous
miR-21	Ubiquitous
miR-28	Ubiquitous
miR-29	Ubiquitous
miR-30a	Nonhematologic cells
miR-30c	Ubiquitous
miR-99a	Ubiquitous (nonhematopoietic)
miR-122	Hepatocytes
miR-126	Endothelial cells, platelets
miR-134	Platelets, iPSC neurons, islet β-cells
miR-143	Smooth muscle cells, fibroblasts, cardiac muscle cells, skeletal muscle cells
miR-144	Red blood cells
miR-145	Smooth muscle cells, fibroblasts, cardiac muscle cells, skeletal muscle cells
miR-146a	Melanocytes, macrophages, lymphocytes, platelets
miR-146b	Dendritic cells, lymphocytes, macrophages
miR-150	Lymphocytes
miR-155	Lymphocytes
miR-182	Epithelial cells
miR-192	Epithelial cells
miR-197	Neutrophils, macrophages, monocytes
miR-200a	Epithelial cells
miR-200b	Epithelial cells
miR-200c	Epithelial cells
miR-210	Ubiquitous
miR-214	Smooth muscle cells, fibroblasts, RPE cells, iPSC neurons
miR-215	Epithelial cells
miR-221	Ubiquitous
miR-223	Macrophages, neutrophils
miR-296	No strong cell signals
miR-323	iPSC neurons
miR-328	Platelets
miR-331	Ubiquitous
miR-342	Macrophages, lymphocytes
miR-361	Lymphocytes
miR-375	Islet β-cells (high expression), colonic epithelial cells (low expression)
miR-378a	Ubiquitous
miR-451	Red blood cells
miR-517	Embryonic stem cells, chorionic membrane cells
miR-637	No strong cell signals
miR-652	Platelets, macrophages, RPE cells
miR-664	Lymphocytes (low expression)
miR-941	Neutrophils, macrophages
miR-4516	No strong cell signals

Abbreviations: iPSC, induced pluripotent stem cell; RPE, retinal pigment epithelium.

Ubiquitous indicates widespread expression, but not necessarily in all cell types.