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. Author manuscript; available in PMC: 2019 Aug 13.
Published in final edited form as: Nature. 2019 Feb 13;566(7744):383–387. doi: 10.1038/s41586-019-0948-2

Extended Data Figure 4. Sleep fragmentation does not alter bone structure and does not depend on the microbiome.

Extended Data Figure 4.

μCT analysis of a, tribeculae and b, cortical bone structure of Apoe−/− mice and Apoe−/− mice after 16 weeks of SF. Bone Volume Fraction (BV/TV), Bone Mineral Density (BMD), Trabecular Number (Tb.N), Trabecular Thickness (Tb.Th), Structural Model Index (SMI), Cortical Tissue Mineral Density (Ct.TMD), Cortical Area (Ct.Ar), Total Area (T.Ar), Cortical Thickness (Ct.Th), Cortical Porosity (Ct.Porosity). (n=9 per group) Analysis of leukocytosis in c, SF and d, Hcrt−/− mice at ZT3 after receiving 4 weeks of antibiotic cocktail in drinking water (n=3 per group). Data presented as mean ± s.e.m., *p<0.05,**p<0.01,***p<0.001, Mann-Whitney two-tailed tests.