FIGURE 10.

Transcriptional networks regulating differentiation of alveolar epithelial cells during the saccular stage of mouse lung development. A: NKX2–1 (aka TTF-1, green) identifies epithelial cells in acinar tubules at the canalicular stage of mouse lung development (E16.5). Endothelial cells of the pulmonary microvasculature are shown by EMCN (red) (A and B). NKX2–1 (blue-green) identifies AT2 cells in mouse alveoli at PN28 (B) at which time alveolar capillary networks are stained by EMCN (red) (C). AT1 (AGER in red) and AT2 cells (NKX2–1, green) are shown in human lung tissues at 4 mo of age. Acta2 (white) stains myofibroblasts seen at alveolar tips (C). Transcription factors influencing AT2 and AT1 differentiation are shown in the schematic.