FIGURE 18.

A predicted transcriptional network regulating differentiation of the pulmonary mesenchyme. A predicted mesenchymal cell gene regulatory network consists of representative transcription factors (green), signaling molecules (orange), and target genes (yellow). Regulatory relationships between key transcriptional regulators and signaling predicted targets were identified through literature mining using the Ingenuity knowledge database. Solid lines indicate direct regulatory relationships. Dashed lines indicate indirect regulatory relationships.