Figure 1.

Characterization of TP53 mutations. Number of mutations indicated in bar plots [regardless of del(17p)] and the number of patients according to TP53 status indicated in pie charts]. (A) Located within exons 4–8, 49 mutations were detected in 41 of 290 newly diagnosed patients; 6 of 7 del(17p) patients also harbored TP53 mutations. Eighteen (37%) and 31 (63%) mutations classified as high and low burden, respectively. (B) Fifty-seven TP53 mutations within exons 4–9 were detected in 17 of 61 patients at time of treatment; 5 of 6 del(17p) patients also harbored TP53 mutations. Nine (16%) and 48 (84%) mutations classified as high and low burden, respectively. Primarily missense mutations were detected. All percentages indicate variant allele frequencies (VAF). TP53 mutation without del(17p) (TP53mut).