Table 1. Summary and characteristics of three independent GWAS datasets used in the study.
| OncoArray N = 32,661 |
Affymetrix N = 10,347 |
GELCC N = 1,430 |
||||
|---|---|---|---|---|---|---|
| Discovery | Replication 1 | Replication 2 | ||||
| No. Sample | Cases n = 18,401 | Controls n = 14,260 | Cases n = 4,950 | Controls n = 5,397 | Cases n = 686 | Controls n = 744 |
| Agea | 63.8 | 61.6 | 62.9 | 60.4 | 61.6 | 64.9 |
| Male (%) | 62.5 | 60.3 | 53.9 | 53.4 | 38.9 | 35.6 |
| Smoking status | ||||||
| Never (%) | 9.7 | 32.1 | 9.7 | 29.8 | 13.0 | 40.1 |
| Former (%) | 38.7 | 39.7 | 36.2 | 35.2 | 87.0c | 59.9c |
| Current (%) | 51.6 | 28.2 | 54.1 | 34.9 | NA | NA |
| Packyrb | 40.7 | 29.8 | 28.9 | 27.6 | NA | NA |
| Histology | ||||||
| NSCLC (%) | 73.9 | 63.3 | 70.8 | |||
| ADE (%) | 38.9 | 36.4 | 40.7 | |||
| SQC (%) | 25.1 | 19.9 | 14.3 | |||
a and b, average statistics for age and packyr (pack year) are provided. c, includes both current and former smokers.