Table 3. TCGA data analysis of DICER1 mutant cases.
| ID | TCGA-EL-A3D5 | TCGA-EL-A3GO | TCGA-EM-A2CT | |||
|---|---|---|---|---|---|---|
| Histology | CVPTC | CVPTC | FVPTC | |||
| DICER1 mutation | E1813G | D1810H | R1906S | |||
| DICER1 mutation domain | RNase IIIb | RNase IIIb | double-stranded RNA binding | |||
| Other mutations |
TP53 NCAN NAB2 ABCB11 RPAP1 TSPYL2 AMDHD1 |
E343Afs*3 P1274S L495Cfs*22 Q216* L628R X413_splice D334Ifs*20 |
SHQ1 ARHGEF6 SLITRK3 TECPR1 DNAH1 HEATR6 DYNC2H1 SBF2 CSMD2 CCDC24 OR51F1 STAC2 |
D13H W439C R809W W763Gfs*56 R4133S K437N G1396Efs*2 I1545S M2857T A44V K306N E241K |
NRAS IRS1 TP73 SYNJ2 OSMR WDR7 NGEF KRTAP4-12 SLC9A4 |
Q61R M664I E40G S1032Y D692G X1277_splice L681P R192H K622N |
| Copy number alteration | PDE3A | AMP | PTPRT | AMP |
DUSP22 IRF4 EXOC2 HUS1B SLC8A1 CBLN2 NETO1 LINC01541 LOC400655 LINC02582 |
AMP AMP AMP AMP DEL AMP AMP AMP AMP AMP |
| Putative driver | DICER1 E1813G | DICER1 D1810H | NRAS Q61R | |||
| DICER1 mRNA expression percentile | 99.18 | 99.59 | 60.29 | |||
| 5p miRNA percentage percentile | 0.18 | 0.53 | 7.03 | |||
Abbreviations: CVPTC, classic variant of papillary thyroid carcinoma; FVPTC, follicular variant of papillary thyroid carcinoma; AMP, amplification; DEL, deletion.