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. 2019 Mar 8;10(20):1903–1917. doi: 10.18632/oncotarget.26726

Figure 5. HDAC inhibition upregulates IFN-γR1 expression in MM cells.

Figure 5

(A) IFNGR1 expression in MM cells. KMS-11, MM.1S and OPM-2 cells were cultured for 6 or 24 hours with or without 25 nM of panobinostat in the presence or absence of 100 U/ml of IFN-γ. IFNGR1 mRNA expression was analyzed in the MM cells by RT-PCR. PPIE was used as an internal control. (B) Surface expression of IFN-γR1 on MM cells. KMS-11, MM.1S and OPM-2 cells were cultured for 24 hours with or without 25 nM of panobinostat (upper) or 1 μM of MS-275 (lower) in the presence or absence of 100 U/ml of IFN-γ. The surface expression of IFN-γR1 was analyzed by flow cytometry. Pano, panobinostat.