Table 3.
Results from the ARIES analyses of maternal education and DNA methylation at 15 years, at 7 years and at birth, for the 20 probes identified as associated with maternal education by EWAS at 15 years
| DNA methylation |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 years |
7 years |
Birth |
||||||||
| Probe | Gene | Rank | β | P-value | Rank | β | P-value | Rank | β | P-value |
| cg21013866 | EFS | 1 | 0.121 | 2.39e-07 | 142 039 | −0.015 | 0.471 | 84 269 | −0.021 | 0.200 |
| cg27187881 | NAGA | 2 | 0.070 | 3.67e-07 | 161 256 | 0.008 | 0.540 | 126 301 | −0.015 | 0.343 |
| cg01122167 | CAMK2A | 3 | 0.189 | 4.20e-07 | 181 763 | −0.017 | 0.616 | 68 182 | −0.056 | 0.150 |
| cg13483196 | – | 4 | −0.149 | 6.96e-07 | 142 225 | 0.022 | 0.472 | 239 441 | −0.009 | 0.802 |
| cg16582803 | – | 5 | −0.114 | 9.19e-07 | 82 871 | −0.025 | 0.261 | 57 578 | −0.039 | 0.119 |
| cg05806180 | SULF1 | 6 | 0.106 | 1.29e-06 | 34 426 | 0.035 | 0.099 | 49 454 | 0.041 | 0.097 |
| ch.10.295680R | – | 7 | −0.088 | 1.41e-06 | 133 477 | 0.013 | 0.440 | 68 485 | 0.026 | 0.151 |
| cg13093989 | EFCAB2 | 8 | 0.168 | 1.51e-06 | 162 044 | −0.021 | 0.543 | 77 789 | −0.048 | 0.179 |
| cg12050497 | FAM84A | 9 | −0.061 | 1.80e-06 | 227 015 | −0.003 | 0.781 | 240 217 | −0.003 | 0.805 |
| cg22091037 | STARD13 | 10 | −0.083 | 1.98e-06 | 204 341 | −0.006 | 0.697 | 104 306 | 0.020 | 0.265 |
| cg11066033 | THAP4 | 11 | −0.083 | 2.07e-06 | 73 680 | −0.018 | 0.229 | 22 593 | 0.045 | 0.035 |
| cg06237983 | HOXA6 | 12 | 0.064 | 2.38e-06 | 705 | 0.044 | 0.001 | 17 659 | 0.037 | 0.026 |
| cg25316853 | SLC1A3 | 13 | −0.084 | 2.47e-06 | 208 276 | −0.006 | 0.712 | 53 709 | 0.032 | 0.109 |
| cg20483690 | LBR | 14 | −0.085 | 2.69e-06 | 78 050 | 0.021 | 0.244 | 58 245 | 0.033 | 0.121 |
| cg06974483 | SPRY1 | 15 | −0.057 | 2.72e-06 | 24 573 | 0.024 | 0.068 | 88 379 | 0.018 | 0.213 |
| cg05585947 | – | 16 | −0.142 | 3.38e-06 | 253 540 | 0.005 | 0.879 | 233 307 | −0.010 | 0.775 |
| cg05076221 | HOXA5 | 17 | 0.072 | 3.44e-06 | 4686 | 0.042 | 0.010 | 2514 | 0.054 | 0.002 |
| cg11367267 | – | 18 | 0.187 | 3.45e-06 | 105 426 | 0.036 | 0.340 | 236 211 | −0.012 | 0.788 |
| cg22891600 | – | 19 | −0.097 | 3.57e-06 | 181 340 | 0.008 | 0.614 | 95 169 | 0.022 | 0.235 |
| cg25397818 | MAD1L1 | 20 | −0.203 | 3.77e-06 | 210 800 | 0.015 | 0.721 | 182 977 | 0.026 | 0.564 |
Models were adjusted for birthweight, parity, gestational age and sex of the newborn in addition to technical variables: bead array row and bisulphite conversion batch.
Gene, UCSC annotated gene; rank, rank of methylation at birth, 7 and 15 years of age; β, regression coefficient.