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Ras-regulated serine-threonine kinase pathways. TCR-mediated DAG generation activates Ras GTPases, which promote Ras activation and start the MAPK signaling cascades required for Erk1 and Erk2 activation. Erk1 and Erk2 kinase activity controls T cell activation through different substrates that control cytoskeleton remodeling, cell metabolism, transcription, translation and proliferation.
