Table 1. Cell number and proliferating cell number in zones of the neonatal cerebellum of 11β-HSD2−/− mice and C57BL/6 controls.
Age | Genotype | BrdU-labeled cells in EGL | No. cells in EGL | No. cells in ML | No cells in IGL |
---|---|---|---|---|---|
P7 | C57BL/6 | 77±5.9 | 193±11.0 | 22±2.5 | 50±1.6 |
11β-HSD2−/− | 80±6.3 | 167±8.6 | 20±3.1 | 34±1.3* | |
P14 | C57BL/6 | 13±1.7 | 59±5.6 | 57±4.6 | 55±3.0 |
11β-HSD2−/− | 16±2.0 | 55±6.2 | 54±6.3 | 61±1.4 | |
Corticosterone treated | |||||
P14 | C57BL/6 | 15±2.6 | 53±6.9 | 56±4.2 | 52±2.8 |
11β-HSD2−/− | 18±1.4 | 63±3.7 | 48±3.2 | 55±2.0 |
The number of proliferating cells was assessed by BrdU labeling. Cell counts were assessed in a standard area for all cerebellar zones and values for each cerebellum are means of counts from three sections across the midsagittal cerebellum at P7 and 14. Values are means±S.E.M., n=4–5/group. * P<0.05 compared to C57BL/6 control