Table 1. Associations of genetically predicted decreased TSH levels, hyperthyroidism, hypothyroidism, and increased FT4 levels with odds ratio of 13 cardiovascular diseases in UK Biobank.
| TSH levels | Hyperthyroidism | Hypothyroidism | FT4 levels | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | Cases* | OR (95% CI)† | P | OR (95% CI)† | P | OR (95% CI)† | P | OR (95% CI)† | P |
| Atrial fibrillation | 13 538 | 1.20 (1.13-1.27) | 1.4×10-9 | 1.06 (1.02-1.10) | 0.005 | 0.95 (0.90-1.01) | 0.11 | 0.97 (0.90-1.05) | 0.47 |
| Coronary artery disease | 24 531 | 1.00 (0.96-1.05) | 0.91 | 0.99 (0.96-1.02) | 0.40 | 1.06 (1.02-1.11) | 0.008 | 0.99 (0.93-1.05) | 0.63 |
| Ischemic stroke | 3554 | 1.02 (0.91-1.14) | 0.75 | 1.03 (0.95-1.11) | 0.51 | 1.10 (0.99-1.22) | 0.09 | 1.01 (0.87-1.17) | 0.91 |
| Intracerebral hemorrhage | 1655 | 0.99 (0.84-1.17) | 0.91 | 1.04 (0.93-1.17) | 0.47 | 0.99 (0.84-1.16) | 0.89 | 1.03 (0.83-1.28) | 0.81 |
| Subarachnoid hemorrhage | 1834 | 1.06 (0.91-1.24) | 0.44 | 1.08 (0.97-1.20) | 0.17 | 0.92 (0.79-1.07) | 0.28 | 1.10 (0.89-1.36) | 0.36 |
| Heart failure | 4803 | 1.02 (0.92-1.12) | 0.71 | 0.98 (0.91-1.04) | 0.46 | 1.04 (0.95-1.14) | 0.41 | 1.01 (0.89-1.15) | 0.91 |
| Aortic valve stenosis | 1252 | 1.01 (0.99-1.04) | 0.35 | 1.01 (0.99-1.03) | 0.18 | 1.00 (0.97-1.02) | 0.84 | 1.01 (0.98-1.05) | 0.51 |
| Abdominal aortic aneurysm | 758 | 0.90 (0.71-1.15) | 0.41 | 1.02 (0.86-1.20) | 0.84 | 0.86 (0.68-1.08) | 0.20 | 1.05 (0.76-1.46) | 0.75 |
| Thoracic aortic aneurysm | 231 | 0.65 (0.42-1.01) | 0.06 | 0.60 (0.44-0.81) | 0.001 | 1.47 (0.97-2.23) | 0.07 | 0.64 (0.36-1.13) | 0.13 |
| Deep vein thrombosis | 3514 | 1.07 (1.00-1.15) | 0.05 | 1.00 (0.95-1.05) | 0.93 | 1.04 (0.97-1.11) | 0.28 | 0.98 (0.89-1.08) | 0.65 |
| Pulmonary embolism | 8891 | 1.09 (0.99-1.20) | 0.07 | 1.03 (0.96-1.10) | 0.39 | 1.06 (0.96-1.16) | 0.23 | 0.94 (0.83-1.06) | 0.31 |
| Peripheral arterial disease | 5097 | 1.06 (0.94-1.18) | 0.34 | 0.99 (0.92-1.07) | 0.86 | 1.06 (0.95-1.18) | 0.33 | 0.83 (0.71-0.96) | 0.01 |
| Hypertension | 119 500 | 1.01 (0.98-1.03) | 0.66 | 1.01 (1.00-1.03) | 0.14 | 1.04 (1.01-1.06) | 0.003 | 0.99 (0.96-1.02) | 0.65 |
*
Total number of participants is 367 703.
†
Odds ratios are expressed per one SD decrease of TSH levels, per one unit higher log-odds of hyperthyroidism and hypothyroidism, and per one SD increase of FT4 levels. Hyperthyroidism = TSH levels below the reference range in the population; hypothyroidism = TSH levels above the reference range in the population.