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(A) Proposed catalytic mechanism. (B) pH-dependence of kcat/Km with PAD4 (reproduced with permission from ref. 23 Copyright (2007) American Chemical Society).23 Yellow color indicates the fraction of enzyme in the active form. (C) General inactivation mechanisms for 2-iodoacetamide and 2-chloro-acetamidine. (D) Reverse protonation (RP) and substrate-assisted (SA) mechanisms of inactivation.
