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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Science. 2018 Dec 14;362(6420):eaat8127. doi: 10.1126/science.aat8127

Figure 3. Overlaps and genetic enrichment among dysregulated transcriptomic features.

Figure 3.

A) Scatterplots demonstrate overlap among dysregulated transcriptomic features, summarized by their first principle component across subjects (R2 values; *P<0.05). Polygenic risk scores (PRS) show greatest association with differential transcript signal in SCZ. B) SNP-heritability in SCZ is enriched among multiple differentially expressed transcriptomic features, with downregulated isoforms showing most substantial association via stratified LD-score regression. C) Several individual genes and isoforms exhibit genome-wide significant associations with disease PRS. Plots are split by direction of association with increasing PRS. In ASD, most associations localize to the 17q21.31 locus, harboring a common inversion polymorphism. In SCZ, a significant association as observed with C4A in the MHC locus.