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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Science. 2018 Dec 14;362(6420):eaat8127. doi: 10.1126/science.aat8127

Figure 4. Transcriptome-wide association.

Figure 4.

Results from TWAS prioritize genes whose cis-regulated expression in brain is associated with disease. Plots show conditionally-independent TWAS prioritized genes, with lighter shade depicting marginal associations. The sign of TWAS Z-scores indicates predicted direction of effect. Genes significantly up or downregulated in disease brain are shown with arrows, indicating directionality. A) In SCZ, 193 genes (164 outside of MHC) are prioritized by TWAS at Bonferroni-corrected P<0.05, including 107 genes with conditionally independent signals. Of these, 23 are also differentially expressed in SCZ brain with 11 in the same direction as predicted. B) Seventeen genes are prioritized by TWAS in BD, of which 15 are conditionally independent. C) In ASD, TWAS prioritizes 12 genes, of which 5 are conditionally independent.