Table III.
Mean difference in age (months) at timing of puberty in boys and girls according to parental time to pregnancy and use of medically assisted reproduction (MAR), the Puberty Cohort, Denmark, 2012–2018.
| Analytic approach | ||
|---|---|---|
| Robust variance estimationa on censored data | GSEM on continuous data | |
| Exposure | Age differenceb | Age differenceb |
| Boys (n = 6299) | ||
| TTP: ≤5 mo | Ref. | Ref. |
| TTP: 6–12 mo | 0.86 (−0.16; 1.88) | 0.61 (−0.06; 1.28) |
| TTP: >12 mo | 0.41 (−0.82; 1.64) | 0.59 (−0.25; 1.42) |
| TTP: 6–12 mo + MAR | 0.43 (−2.43; 3.28) | 0.24 (−1.65; 2.14) |
| TTP: >12 mo + MAR | −0.01 (−1.28; 1.26) | 0.30 (−0.60; 1.20) |
| Girls (n = 6641) | ||
| TTP: ≤5 mo | Ref. | Ref. |
| TTP: 6–12 mo | −0.52 (−1.53; 0.50) | −0.59 (−1.39; 0.20) |
| TTP: >12 mo | −0.75 (−1.94; 0.44) | −0.51 (−1.49; 0.46) |
| TTP: 6–12 mo + MAR | −0.40 (−3.58; 2.78) | −0.39 (−3.13; 2.35) |
| TTP: >12 mo + MAR | −1.21 (−2.61; 0.19) | −1.04 (−2.17; 0.10) |
GSEM, generalized structural equation model; mo, months; TTP, time to pregnancy.
aRobust variance estimation using the Huber–White method.
bMean monthly differences (95% confidence interval) between exposure groups adjusted for parity, maternal age at menarche, age at delivery, pre-pregnancy body mass index, smoking during first trimester and the highest social class of the parents. Analyses included sampling and selection weights.