Table 4.

Cox regression modelling; HRs for septal pacing for primary and secondary endpoints

Endpoint	Model	HR	95% CIs
Primary composite endpoint	1 (Unadjusted)	0.86	0.64 to 1.15
	2 (Age, gender)	1.02	0.76 to 1.36
	3 (Age, gender comorbidities*)	0.97	0.72 to 1.30
Secondary endpoints
All-cause mortality	3 (Age, gender comorbidities*)	0.92	0.66 to 1.28
New-onset heart failure	3 (Age, gender comorbidities*)	0.69	0.24 to 1.67
All-cause mortality/new onset heart failure†	3 (Age, gender comorbidities*)	0.90	0.65 to 1.23
Modified composite endpoint‡	1 (Unadjusted)	0.91	0.68 to 1.21
	2 (Age, gender)	1.08	0.81 to 1.45
	3 (Age, gender comorbidities*)	1.02	0.76 to 1.38

*Chronic kidney disease/congestive heart failure/hypertension/diabetes mellitus/ischaemic heart disease.

†All-cause mortality/new-onset heart failure.

‡As per CARE-HF, with pulmonary embolism and ruptured aortic aneurysm excluded.

CARE-HF, CArdiac REsynchronization in Heart Failure trial.