Table 2.
Multivariable-adjusted associations between pregnancy complications and myocardial infarction, heart failure and stroke
| All eligible pregnancies N=1 662 045 |
Myocardial infarction MV-adjusted HR (95% CI) n=558 |
Heart failure MV-adjusted HR (95% CI) n=3284 |
Stroke MV-adjusted HR (95% CI) n=973 |
| PPCM n=558 1.66 per 1000 PY |
13.0 (4.1 to 40.9) n=<10* PY NA |
39.2 (30.0 to 51.9) n=56 2.19 per 1000 PY |
7.7 (2.4 to 24.0) n=<10* PY NA |
| No PPCM (referent) n=1 661 487 0.58 per 1000 PY |
1.0 n=549 0.98 per 1000 PY |
1.0 n=3228 1.22 per 1000 PY |
1.0 n=964 1.01 per 1000 PY |
| HDP subtypes | |||
| Chronic HTN n=12 458 0.54 per 1000 PY |
6.3 (4.6 to 8.7) n=47 0.90 per 1000 PY |
3.9 (3.3 to 4.7) n=152 1.12 per 1000 PY |
3.4 (2.4 to 4.8) n=37 0.88 per 1000 PY |
|
Gestational HTN n=43 073 5.98 per 1000 PY |
2.3 (1.6 to 3.4) n=28 0.98 per 1000 PY |
2.5 (2.1 to 2.9) n=188 1.39 per 1000 PY |
1.4 (1.0 to 2.0) n=33 1.15 per 1000 PY |
| Pre-eclampsia n=56 419 0.59 per 1000 PY |
2.5 (1.9 to 3.4) n=49 0.89 per 1000 PY |
3.0 (2.7 to 3.4) n=355 1.69 per 1000 PY |
2.3 (1.8 to 3.0) n=79 1.08 per 1000 PY |
| Chronic HTN and gestational HTN n=4907 0.54 per 1000 PY |
2.0 (0.8 to 4.8) n=<10* PY NA |
3.3 (2.5 to 4.5) n=45 1.16 per 1000 PY |
3.0 (1.7 to 5.4) n=12 1.67 per 1000 PY |
| Chronic HTN and pre-eclampsia n=5743 0.61 per 1000 PY |
5.0 (3.1 to 8.0) n=22 1.01 per 1000 PY |
5.4 (4.5 to 6.6) n=135 1.36 per 1000 PY |
7.6 (5.4 to 10.7) n=43 1.03 per 1000 PY |
| No HTN/pre-eclampsia/gestational HTN (referent) n=1 539 445 0.57 per 1000 PY |
1.0 n=407 1.00 per 1000 PY |
1.0 n=2409 1.17 per 1000 PY |
1.0 n=769 1.01 per 1000 PY |
| Other adverse pregnancy outcomes | |||
| Gestational DM n=107 636 0.59 per 1000 PY |
1.0 (0.8 to 1.4) n=57 0.88 per 1000 PY |
1.3 (1.1 to 1.4) n=320 1.36 per 1000 PY |
1.42 (1.2 to 1.8) n=103 1.09 per 1000 PY |
| No gestational DM (referent) n=1 554 409 0.58 per 1000 PY |
1.0 n=501 1.00 per 1000 PY |
1.0 n=2964 1.22 per 1000 PY |
1.0 n=870 1.01 per 1000 PY |
| IUGR n=23 504 0.59 per 1000 PY |
1.6 (1.1 to 2.5) n=23 1.11 per 1000 PY |
1.1 (0.9 to 1.4) n=86 1.22 per 1000 PY |
1.5 (1.0 to 2.1) n=30 1.09 per 1000 PY |
| No IUGR (referent) n=1 638 541 0.58 per 1000 PY |
1.0 n=535 0.98 per 1000 PY |
1.0 n=3198 1.23 per 1000 PY |
1.0 n=943 1.02 per 1000 PY |
| Preterm birth n=116 768 0.58 per 1000 PY |
1.8 (1.4 to 2.3) n=105 1.05 per 1000 PY |
1.6 (1.4 to 1.7) n=532 1.25 per 1000 PY |
1.4 (1.1 to 1.6) n=134 1.05 per 1000 PY |
| No preterm birth(referent) n=1 545 277 0.58 per 1000 PY |
1.0 n=453 0.97 per 1000 PY |
1.0 n=2752 1.23 per 1000 PY |
1.0 n=839 1.01 per 1000 PY |
*In accordance with HCUP policies, categories in which there were fewer than 10 patients are represented simply as <10.
DM, diabetes mellitus;HCUP, Healthcare Cost and Utilization Project; HDP, hypertensive disorders of pregnancy;HTN, hypertension;IUGR, intrauterine growth restriction; MV, multivariate;NA, not available; PPCM, peripartum cardiomyopathy;PY, person-years.