Table 2. Brazilian scale of drugs with anticholinergic activity.
| Score 3 | Score 2 | Score 1 | |||
|---|---|---|---|---|---|
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| ATC | Drug | ATC | Drug | ATC | Drug |
| A03BA04 | Belladonna total alkaloids*, †,a, c, e, f | N04BB01 | Amantadineg, i, l, n | N03AG01 | Valproic acidd, n |
| N06AA09 | Amitriptylineb, c, d, e, f, g, h, i, j, k, l, n | M03BX01 | Baclofenb, f, g, n | N05BA12 | Alprazolamd, f, i, k, n |
| A03BA01 | Atropinea, c, d, f, g, h, i, k, l, n | N03AF01 | Carbamazepined, i, n | J01CA01 | Ampicillind, n |
| N04AA02 | Biperidena, n | A02BA01 | Cimetidined, g, n | C07AB03 | Atenololf, i, n |
| R06AB01 | Brompheniramine*, b, c, d, i, n | M03BB03 | Chlorzoxazone*, b | L04AX01 | Azathioprined, n |
| R06AE01 | Buclizineb | N05AA02 | Cetirizinef, g, k, n | G02CB01 | Bromocriptined, l, n |
| A03BB01 | Butylscopolamine, bromidea | N07BC02 | Levomepromazineb, l, m, n | N06AX12 | Bupropionf, i, n |
| R06AA08 | Carbinoxamineb, c, d, i | N03AF02 | Methadonef, n | C09AA01 | Captoprild, i, n |
| M03BA02 | Carisoprodol*, b, g | N02AB02 | Oxcarbazepined, i, n | N05AN01 | Lithium carbonateh, k, l, n |
| M03BX08 | Cyclobenzaprineb, c, g, h | N05AG02 | Pethidined, i, l, n | J01DC01 | Cefoxitind, n |
| R06AX02 | Cyproheptadineb, c, g, k, l, n | R01BA02 | Pimozided, i, l, n | L04AD01 | Cyclosporined, n |
| R06AA04 | Clemastineb, c, d, i, | R06AE07 | Pseudoephedrine*,b, g, k, n | N06AB04 | Citalopramh, k, l, m, n |
| N06AA04 | Clomipramineb, c, d, e, i, l, n | N05AH04 | Quetiapineb, f, j, l, n | N03AE01 | Clonazepamd, k, m, n |
| R06AB04 | Chlorpheniramineb, c, d, e, f, g, i, k, n | N05BA02 | Chordiazepoxide*, d, f, n | ||
| N05AA01 | Chlorpromazineb,c, d, e, f, g, i, l, n | C03BA04 | Chlorthalidoned, i, n | ||
| N05AH02 | Clozapineb, c, d, h, i, j, l, n | R05DA04 | Codeined, f, i, k, m, n | ||
| G04BD10 | Darifenacina, c, d, i | M04AC01 | Colchicinei, n | ||
| N06AA01 | Desipramineb, c d, i | R06AX27 | Desloratadineb | ||
| R06AB06 | Dexbrompheniramine*, b, c | H02AB02 | Dexamethasoned, n | ||
| R06AB02 | Dexchlorpheniramineb, c, e, k, n | N05BA01 | Diazepamd, f, i, j, k, l, m, n | ||
| R06AA02 | Diphenhydramineb, c, d, f, g, i, n | C01AA05 | Digoxind, i, j, k, n | ||
| R06AA02 | Dimenhydrinateb, c, d, i, n | C08DB01 | Diltiazemd, n | ||
| R06AA09 | Doxylamine*, b, c | B01AC07 | Dipyridamoled, i | ||
| N05AB02 | Fluphenazineb, g, k, n | A03FA03 | Domperidoneb, k, l, m, n | ||
| N05BB01 | Hydroxyzineb, c, d, e, g, i, n | N04BX02 | Entacaponeg, n | ||
| A03BA03 | Hyoscyamine*, a, c, d, g, h, i | N06AB10 | Escitalopramh, k, m | ||
| A03CB04 | Homatropinea, c, f | A02BA03 | Famotidined, n | ||
| N06AA02 | Imipramineb, c, d, e, f, g, i, k, l, n | N03AA02 | Phenobarbitalf, j | ||
| R03BB01 | Ipratropiuma, j, n | N01AH01 | Fentanyld, i, l, m, n | ||
| N06AA21 | Maprotilineb, e, n | R06AX26 | Fexofenadineb | ||
| R06AE05 | Meclizineb, c, d, g, i | N06AB03 | Fluoxetined, f, h, k, l, m, n | ||
| N06AA10 | Nortriptylineb, c, d, f, i, j, l, n | N06AB08 | Fluvoxamined, i, k, n | ||
| N05AH03 | Olanzapineb, c, i, j | C03CA01 | Furosemided, i, j | ||
| M03BC01 | Orphenadrine*,b, c, d, e, i, j, l | J01GB03 | Gentamicind, n | ||
| G04BD04 | Oxybutynina, c, d, e, g, i, j, l, n | N05AD01 | Haloperidolb, g, i, m, n | ||
| N06AB05 | Paroxetinec, i, j | C02DB02 | Hydralazined, i | ||
| R06AD02 | Promethazineb, c, d, g, i, l, n | H02AB09 | Hydrocortisoned, i, n | ||
| G04BD08 | Solifenacina, c, n | C01DA08 | Isosorbided, i, n | ||
| N05AC02 | Thioridazineb, c, d, f, g, h, i, j | R06AE09 | Levocetirizineb, m | ||
| R03BB04 | Tiotropiuma | N04BA02 | Levodopa + carbidopaf, g, k, n | ||
| M03BX02 | Tizanidineb, g, n | A07DA03 | Loperamided, f, i, k, m | ||
| G04BD07 | Tolterodinea, c, d, f, h, i, k, n | R06AX13 | Loratadineb, f, k | ||
| N04AA01 | Trihexyphenidyla, c, d, e, f, i, j, l, n | N05BA06 | Lorazepamd, n | ||
| N05AB06 | Trifluoperazineb, c, g, i | H02AB04 | Methylprednisoloned, n | ||
| R06AX07 | Triprolidineb, c | A03FA01 | Metoclopramideb, g, k, n | ||
| C07AB02 | Metoprololf, i, n | ||||
| N05CD08 | Midazolamd, n | ||||
| N06AX11 | Mirtazapineg, h, l, m, n | ||||
| N02AA01 | Morphined, f, i, m, n | ||||
| C08CA05 | Nifedipined, i, n | ||||
| N02AA05 | Oxycodoned, f, k, m, n | ||||
| J01CA12 | Piperacillin*, d, n | ||||
| N04BC05 | Pramipexoleg, n | ||||
| H02AB06 | Prednisoloned, l, n | ||||
| H02AB07 | Prednisoned, i, n | ||||
| A02BA02 | Ranitidineg, h, i, k, m, n | ||||
| N05AX08 | Risperidoneb, f, g, i, k, m, n | ||||
| N04BD01 | Selegilineg, n | ||||
| N06AB06 | Sertralined, f, l, n | ||||
| R03DA04 | Theophyllined, i, m, n | ||||
| N02AX02 | Tramadold, m, n | ||||
| N02AX05 | Trazodonef, g, i, m, n | ||||
| H02AB08 | Triamcinoloned, n | ||||
| C03DB02 | Triamterene*, d, i, n | ||||
| J01XA01 | Vancomycind, n | ||||
| B01AA03 | Warfarined, n | ||||
| N06AX16 | Venlafaxinef, k | ||||
* Drugs marketed only in a combined, fixed dose; † Fluid extract of Atropa belladona Linné. aAnticholinergic drugs described by Puustinen et al.,( 24 ) and Brown et al.;( 25 )bdrugs with known anticholinergic activity described by Nishtala et al.,( 2 ) Salahudeen et al.,( 8 ) Hilmer et al.,( 23 ) and Puustinen et al.;( 24 )cdrugs with strong anticholinergic activity described in the 2015 American Geriatrics Society Beers Criteria;( 26 )dAnticholinergic Drug Scale;( 5 )eAnticholinergic Burden Classification;( 9 )fClinician-Rated Anticholinergic Score;( 10 )gAnticholinergic Risk Scale;( 11 )hSerum Anticholinergic Activity;( 12 ) iAnticholinergic Cognitive Burden Scale;( 13 )jAnticholinergic Activity Scale;( 14 )kAnticholinergic Load Scale;( 15 )lAnticholinergic Effect on Cognition;( 16 )mMuscarinic Acetylcholinergic Receptor Antagonist Exposure;( 4 )nAnticholinergic Impregnation Scale.( 3 )