Table 1.
Physicochemical characteristics of liposome formulations (mean ± SD, n=3)
| Size (nm) | Polydispersity index | Antibody or ATO content (μg/μmol phospholipid) | Drug encapsulation (mg/mL) | |
|---|---|---|---|---|
|
| ||||
| OTR-Lipo | 201±2.9 | 0.240±0.072 | 1.227±0.023 | – |
| Nifedipine-loaded OTR-Lipo | 203±4.8 | 0.237±0.074 | 1.210±0.053 | 3.995±0.019 |
| Salbutamol-loaded OTR-Lipo | 203±6.3 | 0.253±0.064 | 1.218±0.036 | 3.940±0.067 |
| ATO-Lipo | 201±3.8 | 0.220±0.056 | 5.970±0.232 | – |
| Nifedipine-loaded ATO-Lipo | 203±4.7 | 0.273±0.025 | 5.899±0.177 | 4.001±0.012 |
| Salbutamol-loaded ATO-Lipo | 201±4.2 | 0.213±0.051 | 5.942±0.186 | 3.931±0.089 |
| Rabbit IgG immunoliposomes | 201±7.0 | 0.260±0.052 | 1.190±0.106 | – |
| Conventional liposomes | 201±7.7 | 0.260±0.044 | – | – |
Abbreviations: OTR-Lipo, PEGylated immunoliposomes conjugated with anti-oxytocin receptor monoclonal antibodies; ATO-Lipo, atosiban-conjugated PEGylated liposomes.