Fig. 2. Effect of increasing matrix stiffness on myofibroblast phenotype.
Brightfield photomicrographs of colonic myofibroblasts cultured on substrates of increasing matrix stiffness of 0.01% (2.6 kPa), 0.02% (4.3 kPa), 0.08% (15.6 kPa), and 0.16% (28.1 kPa). Myofibroblasts cultured on a standard plastic substrate are shown for comparison.