FIGURE 1.

Illustration of the experimental design. After surgical catheter implantation (day −14), animals were randomized (R) on day 7 after surgery (day −7) to a reduced caloric intake (semistarvation) and endotoxin group (RE; n = 9) or to a normal control feed endotoxin (CE; n = 9) group for 7 d. Both groups subsequently received a lipopolysaccharide (LPS) endotoxin infusion over 24 h. Stable-isotope infusion and blood sampling were performed on days 0, 1, and 2 after the start of the endotoxin infusion.