TABLE 1.
Hemodynamic variables and plasma lactate and pyruvate concentrations during reduced caloric intake and endotoxemia (RE)1
| Time | P 2 | |||||||
| Variable and groups | 0 h | 4 h | 8 h | 24 h | 48 h | Group effect | Time effect | Group × time interaction |
| Temperature (°C) | 0.5 | 0.03 | 0.03 | |||||
| CE | 38.7 ± 0.5 (9)3 | 40.1 ± 1.1 (9) | 40.3 ± 0.7 (9) | 40.4 ± 1.0 (9) | 39.7 ± 1.04 (9) | |||
| RE | 38.7 ± 0.5 (9) | 40.5 ± 0.5 (9) | 40.4 ± 0.6 (9) | 39.7 ± 0.5 (7) | 39.0 ± 0.8 (7) | |||
| MAP (mm Hg) | 0.5 | 0.4 | 0.5 | |||||
| CE | 113 ± 54 (6) | 111 ± 9 (6) | 109 ± 8 (6) | 108 ± 84 (6) | 101 ± 9 (6) | |||
| RE | 104 ± 6 (6) | 101 ± 8 (6) | 105 ± 5 (6) | 96 ± 4 (6) | 106 ± 1 (6) | |||
| CI (mL · kgminus1 · minminus1) | 0.8 | <0.0001 | 0.002 | |||||
| CE | 159 ± 55 (8) | 183 ± 57 (8) | 200 ± 57 (8) | 190 ± 42 (6) | 165 ± 44 (6) | |||
| RE | 151 ± 27 (6) | 218 ± 57 (6) | 259 ± 23 (6) | 238 ± 16 (6) | 147 ± 12 (6) | |||
| pHa | 0.004 | <0.0001 | <0.0001 | |||||
| CE | 7.44 ± 0.04 (9) | 7.39 ± 0.04 (9) | 7.41 ± 0.034 (9) | 7.43 ± 0.03 (8) | 7.46 ± 0.03 (8) | |||
| RE | 7.46 ± 0.02 (9) | 7.39 ± 0.08 (9) | 7.36 ± 0.06 (9) | 7.45 ± 0.03 (6) | 7.47 ± 0.04 (6) | |||
| BE (mEq/L) | 0.4 | 0.006 | ||||||
| CE | 3.9 ± 2.3 (9) | −1.0 ± 3.6 (9) | −1.0 ± 1.44 (9) | 0.4 ± 3.8 (8) | 5.8 ± 3.0 (8) | 0.04 | ||
| RE | 4.0 ± 2.3 (9) | −1.7 ± 3.2 (9) | −4.8 ± 4.3 (9) | 2.0 ± 1.4 (6) | 6.2 ± 1.8 (6) | |||
| P mCO2 (kPa) | 0.2 | 0.02 | <0.0001 | |||||
| CE | 6.2 ± 0.6 (9) | 7.2 ± 1.3 (9) | 6.2 ± 0.24 (9) | 7.6 ± 1.4 (8) | 6.6 ± 1.64 (8) | |||
| RE | 5.8 ± 1.0 (9) | 7.3 ± 0.6 (9) | 6.9 ± 1.3 (9) | 8.3 ± 0.4 (6) | 8.8 ± 0.5 (6) | |||
| P m-aCO2 (kPa) | 0.2 | 0.002 | 0.002 | |||||
| CE | 0.6 ± 0.8 (9) | 1.7 ± 0.8 (9) | 2.1 ± 0.9 (9) | 1.3 ± 0.84 (8) | 0.9 ± 1.44 (8) | |||
| RE | 1.2 ± 1.4 (9) | 1.9 ± 0.7 (9) | 1.9 ± 0.1 (9) | 3.3 ± 0.5 (6) | 3.4 ± 0.4 (6) | |||
| Lactate (mmol/L) | 0.001 | 0.005 | 0.04 | |||||
| CE | 1.6 ± 1.0 (9) | ND | ND | 5.7 ± 6.9 (9) | 0.9 ± 0.3 (8) | |||
| RE | 1.9 ± 1.2 (9) | 5.3 ± 7.3 (6) | 0.8 ± 0.1 (6) | |||||
| Pyruvate (mmol/L) | 0.8 | 0.01 | 1.0 | |||||
| CE | 0.5 ± 0.6 (9) | ND | ND | 1.4 ± 2.5 (9) | 0.3 ± 0.5 (8) | |||
| RE | 0.2 ± 0.1 (9) | 0.3 ± 0.5 (6) | 0.1 ± 0.1 (6) | |||||
| L/P ratio | 0.2 | 0.3 | 0.2 | |||||
| CE | 9.1 ± 1.1 (9) | ND | ND | 7.5 ± 3.64 (9) | 9.8 ± 2.34 (8) | |||
| RE | 12.3 ± 1.0 (9) | 16.1 ± 1.4 (6) | 16.0 ± 1.8 (6) | |||||
1
ND, not determined; MAP, mean arterial pressure; CI, cardiac index; pHa, arterial pH; BE, base excess; PmCO2, intramucosal partial pressure carbon dioxide; Pm-aCO2, mucosal minus arterial PCO2; L/P, lactate/pyruvate; CE, control endotoxemia.
2
P for group, time, and interaction effects by repeated-measures ANOVA.
3
Mean ± SD; number of animals per time group in parentheses (all such values); n values <9 represent missing data (the last observation carried forward principle was used to replace missing data).
4
Significantly different from RE, P < 0.05.