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. 2019 Feb 28;52(2):127–132. doi: 10.5483/BMBRep.2019.52.2.257

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Copyright © 2019 by the The Korean Society for Biochemistry and Molecular Biology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Transcriptional memory in immune cells. (A) Monocyte exposed to immune stimulation such as lipopolysaccharide (LPS) or beta-glucan exhibits different levels of H3K4me1, H3K4me3 and H3K27ac globally even after differentiation into macrophage. (B) Effector T cell exhibits transcriptional memory upon 2nd stimulation. At that time, the chromosomal allelic pairing and Pol II pausing are occurred at locus of the related genes, which lead to bi-allelic RNA expression and finally rapid gene expression.