Table IV.
Functional classification of the differentially-expressed proteins, identified by liquid chromatography tandem mass spectrometry, in T2DM.
| No. | Class of proteins | No. of proteins | Upregulation in T2DM | Downregulation in T2DM |
|---|---|---|---|---|
| 1 | Immunity (largely antibodies) | 18a | 15 | 3 |
| 2 | Undefined class | 7 | 3 | 4 |
| 3 | Enzyme regulator | 6 | 4 | 2 |
| 4 | Hemoglobin chains and hemoglobin binding | 5 | 3 | 2 |
| 5 | Cell adhesion | 4 | 4 | 0 |
| 6 | Catalytic: enzymes | 4 | 2 | 2 |
| 7 | Signal transduction | 4 | 2 | 2 |
| 8 | Lipid metabolism and transport | 3 | 2 | 1 |
| 9 | Transport | 3 | 3 | 0 |
| 10 | Blood coagulation | 2 | 2 | 0 |
| 11 | Regulatory | 2 | 2 | 0 |
| 12 | Transcription factor | 2 | 1 | 1 |
| 13 | Cytoskeletal protein | 1 | 1 | 0 |
| 14 | RNA binding | 1 | 1 | 0 |
| 15 | Secretory | 1 | 1 | 0 |
| 16 | Spermatogensis | 1 | 0 | 1 |
| Total | 62 | 46 | 18 |
a
Two proteins were both up- and downregulated, but in a different set of sera (depleted and non-depleted). Additionally, a number of proteins belong to multiple classes. T2DM, type 2 diabetes mellitus.