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. 2019 Mar 6;43(5):2103–2117. doi: 10.3892/ijmm.2019.4126

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Copyright: © Miao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Conditional knockout of Fam20c leads to an altered BMP4 distribution pattern and altered BMP expression in the SMG. (A) IHC of BMP4 in the SMG. In control mice, BMP4 was localized in the cytoplasm of ducts cells (black arrows) and ECM (arrowheads). In the cKO mice, BMP4 was restricted to ducts (black arrows). For images of Fam20c^f/f or Fam20c^f/f; Mmtv-cre mice, the second panel presents magnified images of the outlined areas from the corresponding panel. IHC of BMP signaling pathways components in the SMG. IHC reaction to (B) pan-Smad1/5/9, (C) p-Smad1/5/9, pan-ERK and pan-p38 were detected in the cytoplasm of duct cells (black arrows) while the signals against p-Erk and p-p38 were observed in the nucleus (red arrows). IHC, immunohistochemistry; BMP, bone morphorgenic protein; Smad, mothers against decapentaplegic homolog 9; p-, phosphorylated; ERK, extracellular signal regulated kinase; Fam20C, cKO, Fam20c^f/f; Mmtv-Cre conditional knockout; family with sequence similarity 20-member C.