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H2S inhibits PCSK9 expression in HepG2 cells in a concentration-dependent manner. HepG2 cells were treated with various concentrations of NaHS (0, 50, 100 and 200 µmol/l). (A and B) The protein levels of PCSK9 were detected by western blot analysis (*P<0.05 and **P<0.01 vs. the 0 µmol/l NaHS group) (n=3). H2S, hydrogen sulfide; NaHS, sodium hydrosulfide; PCSK9, proprotein convertase subtilisin/kexin type 9.
