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PCSK9 siRNA increases the uptake of DiI-LDL by HepG2 cells (magnification, ×400). DiI-LDL was incubated with the HepG2 cells for 4 h, and the DiI-LDL uptake by HepG2 cells was detected. PCSK9, proprotein convertase subtilisin/kexin type 9; DiI-LDL, 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocar-bocyanine perchlorate-labeled LDL.
