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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 24;61(17):7700–7709. doi: 10.1021/acs.jmedchem.8b00669

Figure 1.

Figure 1.

Dose response and morphology of explants treated with AT7519 and cisplatin. (A) The chemical structure of AT7519. (B) The dose response of AT7519 in P3 cochlear explants of mice treated with cisplatin (150 μM). OHC counts for media alone were considered as complete protection from cisplatin-induced toxicity and OHC counts for cisplatin alone were considered as no protection. Number of explants tested indicated within each bar. Cell counts for explants treated with cisplatin + AT7519 (25 nM) were significantly different from explants treated with cisplatin alone (*P < 0.05). A dosing curve could not be generated because of a loss of efficacy at higher doses.