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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 24;61(17):7700–7709. doi: 10.1021/acs.jmedchem.8b00669

Figure 3.

Figure 3.

Effect of analog 7 on cisplatin-induced ototoxicity when administered 1 h before cisplatin administration. P30 FVB mice received analog 7 (50 μM) in saline with 0.5% DMSO (5 μL) by transtympanic injection of the left ear. The ABR of the left ear of each mouse was recorded before treatment and again 15 days after. The data in the figure represent the mean change in threshold shifts before and after treatment for each group. The threshold shifts at 16 and 32 kHz in mice treated with analog 7 + cisplatin were significantly different from those in mice treated with vehicle alone and cisplatin (16 kHz, P = 0.0075; 32 kHz, P = 0.0288) or with vehicle alone and no cisplatin (32 kHz, P = 0.0235). Results are presented as the mean ± SEM. *P < 0.05 and **P < 0.01 by the paired 2-tailed t-test.