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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 24;61(17):7700–7709. doi: 10.1021/acs.jmedchem.8b00669

Figure 6.

Figure 6.

Effect of AZD5438 on cisplatin-induced ototoxicity in adult FVB mice when dosed 1 h before cisplatin administration and again 24 h after cisplatin administration. P30 FVB mice received AZD5438 (50 μM) in saline with 0.5% DMSO (5 μL) by transtympanic injection of the left ear. The ABR of the left ear of each mouse was recorded before treatment and again 15 days after treatment. The data in the figure represent the mean ABR threshold shifts before and after treatment for each group. The threshold shifts at 32 kHz for mice treated with the analog AZD5438 + cisplatin were significantly different from those for mice treated with cisplatin alone (32 kHz, P = 0.002). Results are presented as the mean ± S.E.M. **P < 0.01 by the paired 2-tailed t-test.