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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 24;61(17):7700–7709. doi: 10.1021/acs.jmedchem.8b00669

Figure 8.

Figure 8.

Kinase Interaction Maps of kenpaullone, AZD5438, AT7519, and analog 7. aReported data for kinome scan against 234 kinases with kenpaullone.26 bKinome scan against 468 kinases by DiscoverX. All compounds were tested at 1 μM. A high level of selectivity for kinases in the CMGC kinase group was observed for AT7519, analog 7, and AZD5438, and significant overlap for GSK3A, GSK3B, and members of the CDK family was observed for all four compounds.