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Top Protective Compounds in HEI-OC1 Cell Assay and Cochlear Explants
| Name | HEI-OC1 EC50 (μM) | Explant EC50 (μM) |
|---|---|---|
| AZD5438 | 0.700 | 0.005 |
| AT7519 | 0.380 | 0.025a |
| Kenpaullone | 0.349 | 0.150b |
| BIO | 0.192 | 0.570c |
| CDK2 inhibitor II | 0.127 | 1.000b |
| Olomoucine II | 0.595 | 3.000b |
| SU9516 | 1.594 | 6.000c |
| AZD1080 | 3.634 | 15.000c |
EC50 could not be determined; maximal protection was observed at 25 nM.
Report by Teitz et al.17
Estimated EC50 based on 2–3 tested dose concentrations.
