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. Author manuscript; available in PMC: 2019 Sep 13.

Published in final edited form as: J Med Chem. 2018 Aug 24;61(17):7700–7709. doi: 10.1021/acs.jmedchem.8b00669

Table 2.

Cellular Activity of Selected Analogs of AT7519


Compound	R¹	R²	R³	HEI-OC1 EC₅₀ (μM)	CDK2 IC₅₀ (μM)
AT7519			H	0.380	0.047^a
1			H	>32.219	0.090^a
2			H	>33.208	0.140^a
3			H	>32.714	1.600^a
4			H	0.507	0.003^a
5			H	0.044	0.025^a
6			H	>27.260	0.012^a
7			H	0.013	0.019^a
8			H	>33.457	0.038^a
9			H	>37.918	0.044^a
10			H	22.463	0.140^a
11			H	>30.855	0.750^a
12			H	>37.1747	0.035^a
13			H	2.606	0.110^a
14			H	0.459	760.2^b
15			Me	>49.442	>10^b
16			Et	31.149	>10^b
17			Et	5.039	>10^b
18			Et	6.753	>10^b

^a

Reported by Wyatt et al.²¹

^b

From this work.