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Radioactive HPLC profile of 203Pb-DOTA-GGNle-CycMSHhex (A, TR = 18.3 min) and its mouse serum stability (B) after 4 h incubation at 37 °C. Radioactive HPLC profile of the urine sample of a normal C57 mouse at 2 h post-injection of 203Pb-DOTA-GGNle-CycMSHhex (C). Arrows indicate the original compound of 203Pb-DOTA-GGNle-CycMSHhex. Specific binding of 203Pb-DOTA-GGNle-CycMSHhex on B16/F1 (D) and B16/F10 (E) melanoma cells with or without peptide blockade.
