Table 1.

Biodistribution of ²⁰³Pb-DOTA-GGNle-CyCMSH_hex in B16/F1 murine melanoma-bearing C57 mice. The data were presented as percent injected dose/gram or as percent injected dose (Mean ± SD, n = 5)

Tissues	0.5 h	2 h	2 h blockade	4 h	24 h
	Percent injected dose/gram (% ID/g)
Tumor	14.37 ± 3.43	12.61 ± 2.28	0.68 ± 0.21*	9.37 ± 2.23	6.40 ± 0.37
Brain	0.11 ± 0.04	0.01 ± 0.01	0.01 ± 0.01	0.03 ± 0.02	0.01 ± 0.02
Blood	2.40 ± 0.57	0.25 ± 0.11	0.27 ± 0.12	0.14 ± 0.07	0.09 ± 0.04
Heart	1.0 ± 0.19	0.08 ± 0.09	0.11 ± 0.04	0.07 ± 0.07	0.02 ± 0.03
Lung	2.16 ± 0.29	0.27 ± 0.07	0.24 ± 0.15	0.18 ± 0.04	0.09 ± 0.02
Liver	1.08 ± 0.10	0.64 ± 0.11	0.61 ± 0.11	0.54 ± 0.08	0.52 ± 0.02
Skin	2.16 ± 0.79	0.12 ± 0.08	0.12 ± 0.17	0.11 ± 0.08	0.18 ± 0.13
Spleen	0.61 ± 0.22	0.15 ± 0.15	0.07 ± 0.12	0.13 ± 0.06	0.17 ± 0.10
Stomach	1.10 ± 0.37	0.97 ± 1.09	0.70 ± 0.53	0.49 ± 0.10	1.32 ± 0.49
Kidneys	9.3 ± 1.75	4.99 ± 1.48	4.61 ± 0.75	4.82 ± 0.59	2.77 ± 0.81
Muscle	0.38 ± 0.19	0.07 ± 0.09	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01
Pancreas	0.31 ± 0.18	0.05 ± 0.06	0.04 ± 0.04	0.01 ± 0.01	0.01 ± 0.01
Bone	1.17 ± 0.46	0.35 ± 0.34	0.20 ± 0.26	0.31 ± 0.27	0.46 ± 0.14
	Percent injected dose (% ID)
Intestines	1.04 ± 0.13	1.25 ± 0.65	1.21 ± 0.52	2.13 ± 1.13	2.09 ± 1.56
Urine	78.62 ± 0.59	92.11 ± 3.55	94.25 ± 1.99	93.45 ± 1.0	94.45 ± 1.58
	Uptake ratio of tumor/normal tissue
Tumor/blood	5.99	50.44	2.52	66.93	71.11
Tumor/kidney	1.55	2.53	0.15	1.94	2.31
Tumor/liver	6.65	46.70	2.83	52.06	71.11
Tumor/lung	13.31	19.70	1.11	17.35	12.31
Tumor/muscle	37.82	180.14	68.0	937.0	640.0

^*p<0.05 for determining significance of differences in tumor and kidney uptake between ²⁰³Pb-DOTA-GGNle-CyCMSH_hex with or without peptide blockade at 2 h post-injection.